Last edited by Faulkree
Tuesday, August 11, 2020 | History

3 edition of Protein-Protein Interactions as Drug Targets found in the catalog.

Protein-Protein Interactions as Drug Targets

Anil Sehgal

Protein-Protein Interactions as Drug Targets

Focusing on Cell Circuitry

by Anil Sehgal

  • 5 Want to read
  • 26 Currently reading

Published by D&md Publications .
Written in English

    Subjects:
  • Pharmacology,
  • Medical / Nursing

  • Edition Notes

    ContributionsDrug & Market Development Publications (Other Contributor)
    The Physical Object
    FormatHardcover
    Number of Pages1
    ID Numbers
    Open LibraryOL12271816M
    ISBN 101579363121
    ISBN 109781579363123
    OCLC/WorldCa64696001

      1. Introduction: targeting protein–protein interactions. Pharmaceutical R&D undergoes a decline of productivity as the number of new drugs approved by the FDA regularly decreases,.Besides market forces and difficulties such as demand and competition, pharmaceutical R&D has become increasingly challenging.   Introduction. The classification of protein–protein interactions (PPI) as druggable targets is relatively new. If one considers druggability as the ability to modulate the therapeutic target with a small orally available molecule [], the first review that included small molecules as antagonists of PPI dates from [].However, progress was initially slowed by a focus on discovery tools.

    Protein-Protein Interactions as Potential Targets of Drug Designing Zeeshan Zahoor Banday1; Ghulam Md Ashraf * 1School of Life Sciences, Jawaharlal Nehru University, New Delhi, India *Correspondence to: Ghulam Md Ashraf, King Fahd Medical Research Center, King Abdulaziz University, P. O. Box , Jeddah , Saudi Arabia. Tel: + ; E-mail: @, . Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.

    Get this from a library! Protein-protein interactions as new drug targets. [Enno Klussmann; John Scott, Ph. D.; E M Aandahl;] -- Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with.   A SARS-CoVHuman Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing bioRxiv. Mar 22; doi: / Preprint. Authors David E Gordon.


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Protein-Protein Interactions as Drug Targets by Anil Sehgal Download PDF EPUB FB2

Protein Interactions as Targets in Drug Discovery, Volumeis dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the.

Protein-Protein Interactions as New Drug Targets (Handbook of Experimental Pharmacology): Medicine & Health Science Books @   Modulation of protein–protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this ‘target class’ was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible by:   Abstract.

Over the last two decades, a number of protein-protein interactions (PPIs) have been targeted by the pharmaceutical industry. Pharma as a whole has historically considered PPIs to be undruggable or at the very least high-risk targets, and the relative lack of success in modulating PPIs with small molecules has done little to change this prevailing by: 3.

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions.

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets.

They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side.

Introduction. Modern drug discovery is driven by molecular targets with the aim of identifying new therapeutic agents that can selectively target disease-specific molecular mechanisms or pathways (Díaz-Eufracio et al.

).In this context, protein-protein interactions (PPIs) are an attractive emerging class of molecular targets and are critically important in the progression of many disease.

Disruption or deregulation of these complex interactions is the main cause of a significant number of human ailments. Consequently, there is intense research effort to design inhibitors that target specific protein-protein interactions.

This places intricate protein-protein interactions in the heart of the development for novel drug leads. the modulation (both inhibition and stabilization) of protein–protein interactions (PPIs) in order to develop novel therapeutic approaches and target-selective agents in drug discovery.

Discussion: The diversity and complexity of highly dynamic systems such as PPIs present many challenges for the identification of drug-like molecules with. Protein-Protein Interactions as Drug Targets.

Shaomeng Wang, Yujun Zhao, Denzil Bernard, Angelo Aguilar, Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics. Kurt Deshayes, Jeremy Murray, Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer.

Protein-protein interactions and biosynthetic building blocks may be targeted as well. Other drug targets include lipids and carbohydrates. However, the number of drugs that act on these targets is relatively small compared to drugs that target proteins and nucleic acids.

Further Reading. Drugs, their targets and the nature and number of drug. Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely.

Title:Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View VOLUME: 19 ISSUE: 6 Author(s):Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Syed Anjum, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood and Showkat Ahmad Ganie* Affiliation:Department of Clinical Biochemistry, School of Biological Sciences.

The Book of Longings. Sue Monk Kidd. € €. Protein–protein interactions (PPIs) control a large number of biological processes. An attempt to design novel drug molecules has led to an increasing interest in the protein surfaces. Since the onset of targeted drug discovery, a little before the turn of the millennium, intracellular drug targets have primarily been enzymes that catalyze reactions.

However, a new type of intracellular drug target—Protein-Protein Interactions—are now expanding the space in which to search for new types of medicines.

Drug specific networks. tuberculosis H37Rv interactome obtained, captures interactions of all proteins in the cell, and hence will automatically include interactions of the drug targets as well as the resistome proteins.

Specific sub-networks capturing routes through which information could flow from the ‘source’ to the ‘sink’ nodes can therefore be easily derived from the entire.

ISBN: OCLC Number: Description: xv, pages: illustrations: Contents: PART I: ORGANIZATION OF SCAFFOLDS --A-Kinase Anchoring Proteins as the Basis for cAMP Signaling / K.L.

Dodge-Kafka, A. Bauman, and M.S. Kapiloff --Arrestins as Multi-Functional Signaling Adaptors / V.V. Gurevich, E.V. Gurevich, and W.M. Protein–protein interactions (PPIs) are increasingly being targeted by drug discovery groups, and there exists great scope for therapeutic modulation of this target class in disease.

Protein-Protein Interactions (PPIs) as drug targets commonly refers to the surface of two interacting intracellular proteins or a complex of proteins that can potentially be disrupted or stabilized by a small molecule agent that penetrates the cell. SARS-CoV-2 Protein Interaction Map Reveals Drug Targets A blueprint of how the virus hijacks host cells identified ten repurposed drugs that inhibit .Protein-protein interactions (PPIs) are at the center of almost every cellular process from cell proliferation to cell metabolism and even signal transduction pathways.

Thus it is not surprising that PPIs are of pivotal importance in the development of most diseases. In particular, many intracellular PPIs are compelling targets for the development of cancer therapeutics and neurodegenerative.